ABSTRACT
SARS CoV-2 (COVID-19) is a positive sense ssRNA virus that belongs to the family coronavirus and is disseminating its appendages throughout the world because of the nonexistence of drugs at present-day. Due to its association with respiratory distress, fever, and cough, the mortality rate is more than 15% worldwide. Since 2020, an inspiring number of scientists, biologists, pharmacologists, virologists, immunologists, and molecular biologists, are doing work on the development of biotechnological tools, specifically monoclonal antibodies and vaccines, along with the rational design of pharmaceutical drugs for remedial approaches. Although some vaccines were synthesized, unfortunately, no acceptable remedial approach or anti-COVID-19 preventive has thus far been developed and fully accepted. On the other hand, among all possible ways to combat COVID-19 inhibition or alleviation, there is another way, that is, plant bioactive, which has been given miniature consideration to date. Indeed, in the plants (edible parts) providing our foodstuff, there is an impartial quantity of secondary metabolites. Among all secondary metabolites, flavonoids are the largest class of phytochemicals that are frequently available in aromatic plants. Flavonoids are a large class of secondary metabolites endowed with antiviral properties 254via their capability to constrain viral pathogenesis at an initial phase of the life cycle of the virus, as cited in previous reports on the use of flavonoids on different RNA viruses, like Ebola, influenza, middle east respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and human immunodeficiency virus (HIV). These antiviral activities potentiate the use of Flavonoids as a treatment agent against the SARS-CoV-2. In addition, flavonoids are recognized to have pharmacological features and, via their well-being advantageous activities, for instance, immune-stimulating or else anti-inflammatory actions may perhaps play an important role in subsidizing to a certain extent to preclude or aggravate the virus infection and/or neutralize the progress of SARS prompted by the new coronavirus (CoV). To that end, an inclusive chapter on the role of flavonoids and their antiviral prospective against COVID-19 has been undertaken.
