ABSTRACT
Flavonoids are well-known naturally occurring biomolecules founds to be effective antivirals. These biomolecules can act directly and indirectly at various steps of viral infection. Flavonoids from plants serve as an untapped reservoir of therapeutically active constituents that needs to be explored as potential antiviral candidates against RNA and DNA viruses. Further, structure-based studies can play a crucial role in identifying antiviral activity showing flavonoids. Despite many efforts, very few flavonoids are in clinical trials for antiviral treatment against various virus infections. Here, flavonoids as evidence-based natural sources of antivirals against a number of classes of viruses have been discussed.
