ABSTRACT
One of the most important plant families is the Asteraceae, and their medicinal effects are attributed to phytochemical compounds such as polyphenols, synthetic resin acids, flavonoids, acetylenes, and triterpenes. Nowadays, there is a growing interest in natural sources, which has sparked study interest in the Asteraceae family. The majority of non-infectious diseases are developed and worsened by prolonged and persistent chronic inflammation. The prevailing therapies for many of those chronic diseases generally cause a lot of deleterious side effects, warranting the requirement of safer, less toxic, and less expensive treatment for patients. For hundreds of years, flavonoids and their preparations were used to treat numerous human diseases. Recent studies have additionally shown that flavonoids, particularly flavone derivatives, regulation of pro-inflammatory mediators such as cyclooxygenase, shown unique therapeutic activity, inducible nitric oxide synthase (iNOS), 122and a number of other cytokines. Because of these diverse mechanisms of action, flavonoids are thought to be affordable candidates for drug development. Understanding the involvement of inflammatory mediators in several disease conditions and, additionally, the mechanism of action of phytochemical compounds from natural sources can open the way for herbal drug development against inflammatory diseases. The chapter explored the role of flavonoids of plants of the Asteraceae family in combating several inflammatory processes underlying chronic disease conditions.
