ABSTRACT
The generation of different types of blood cells from a single hematopoietic stem cell is a well-coordinated process involving epigenetics in cell fate decisions and lineage commitments. DNA methylation, histone protein modifications, and chromatin remodeling are the three main epigenetic mechanisms by which histone protein modifications play a prominent role in gene regulation during development and differentiation. Among the several histone protein modifications, acetylation and deacetylation of lysine residues in the N-terminal region of histone proteins are crucial for cell fate commitment. The role of the enzymes involved in this modification during hematopoietic lineage commitment has been explored.
