ABSTRACT
Biological monitoring of exposure can overcome many of the limitations of these kinds of studies for the assessment of human risk. To establish the association between biological monitoring and exposure dose is of particular interest. The methods currently available for biomonitoring of exposure can measure early biological effects, internal dose, or biologically effective dose. A Chromosome aberration analysis is the most extensively employed method to assess the early effects of exposures to genotoxic agents. It has been demonstrated on a population basis that there is an increase in SCE due to the exposure of known mutagens and carcinogens. It has been suggested that the application of this procedure to the biological monitoring of exposure in population groups is limited by the lack of chemical specificity. Biological monitoring of exposure is of particular interest, since genetic factors are highly important in their metabolism.
