ABSTRACT
It is well known that hyperlipoproteinemia is often related to coronary and cerebrovascular diseases. These alterations are invariably present in patients and in experimental animals affected by renal disturbances such as nephrotic syndrome and chronic renal failure. However, lipoprotein disturbances in acute renal failure (ARF) have not been studied in humans or in animals. Such studies are extremely difficult in humans, since hyperlipidemia already accompanies many of the causes of ARF. On the other hand, animal intoxication with uranyl nitrate has been used as an experimental model for ARF. Several morphological and functional disturbances which occur in the kidneys of uranyl acetate-treated animals have been described previously. Hence, the aim of this chapter was to ascertain the presence or absence of lipoprotein disturbances in rats with ARF.
