ABSTRACT
Cyclosporine A (CsA), a potent immunosuppressive agent, has in recent years been used increasingly in renal transplantation, resulting in improved allograft survival. This chapter describes the management of successful pregnancies in three patients receiving CsA after kidney transplantation. Maternal renal function was followed by BUN, serum creatinine levels, creatinine clearance, and protein excretion. With the improvement in both length and quality of life of renal transplant recipients, pregnancy in such patients has become a more frequent occurrence. To date, cases reported in the literature have not shown a significant harmful effect of CsA on fetal development or on the allograft survival. CsA is a lipid-soluble compound, highly protein bound and almost completely eliminated by hepatic metabolism. In conclusion, there appears to be no contraindication to the use of CsA in pregnancy of renal transplant recipients, when close monitoring is provided.
