ABSTRACT
There is a hereditary tendency in all diseases. Large worldwide consortia are uncovering genetic differences that relate to complex disorders using GWAS. However, nutrient data are lacking, which is crucial for developing dietary (Keservani et al., 2010a; b; Keservani et al., 2020) recommendations for disease prevention and management. Nutrigenetics and nutrigenomics research focuses primarily on nutritional and gene connections in health and disease, which is critical for individualized nutrition. When gene-nutrientdisease connections are ready to be analyzed as possible instruments to enhance public health, a process will be required. The innovative and promising topic of nutrigenomics and nutrigenetics is the focus of this edition of “Development in Translational Science and Molecular Biology.” The first chapter entails the foundational concepts required for understanding the content presented in the remaining chapters of the book. The idea of individualized nutrition is highlighted, as is its potential function in public health, illness prevention, and therapies. Nutrigenetics is the scientific study of the importance of nutrients in gene expression, while nutrigenomics is the study of the role of nutrients in the expression of genes. Diet has influenced gene expression throughout human history, resulting in phenotypes that can successfully adapt to environmental challenges and allow improved 2exploitation of food resources. Human development and growth have been aided by these adaptations. Due to technological innovations, it is possible to study not only a single gene but also the entire genome-wide complement of DNA sequence variations, or transcriptomes, in unbiased designs. These breakthroughs offer a chance to lay the groundwork for incorporating biological individuality into dietary recommendations, which could have important and deep impacts.
