ABSTRACT
The use of liposomes to aid drug distribution has already a significant influence on the delivery of poorly bioavailable drugs. The discovery of the phospholipid vesicles also coincides with the establishment of the fact that cell membranes are primarily composed of the lipid bilayer, which mainly acts as a permeability barrier for all the cells. Hydrophilic molecules can be confined in the aqueous core, while hydrophobic molecules are embedded into the outer bilayer membrane. The glycolipids can be grafted onto the surface of the liposomes to decrease cellular absorption by RES cells and lengthen the circulation period. A literature survey also suggested that neutral liposomes can be protected against aggregation-dependent absorption by including a modest quantity of negatively charged lipids in them. Thin-film hydration is the most popular technique used to prepare liposomes. Mixed micelles form in the solution when the lipid film is hydrated in an aqueous buffer.
