ABSTRACT
Presently, 90% of drugs in the pharmaceutical industry are hydrophobic or poorly water-soluble, which leads to obstruction in the development of novel drugs and formulations. Recently, nanoemulsions (NEs) have attained considerable attention among researchers to design various drug delivery systems in pharmaceutical applications by various routes. Hydrophobic drugs face more challenges to deliver orally, due to their poor biopharmaceutical properties and hence poor bioavailability. Researchers focused on such nanocarriers greatly in the last decade due to the dynamic characteristics of their lipid components. NEs have a great future as powerful nanomedicines and can be acted as nextgeneration smart nanomaterials as they possess high solubilization capabilities and reduce the severe toxic effects of drugs. NEs have improved physical stability, as they do not undergo the characteristic destabilizing mechanism such as creaming, flocculation, coalescence, and sedimentation associated with macroemulsions. Mainly NEs are prepared using surfactants, oils, and co-surfactants.
