ABSTRACT
Decellularized tissue is an extracellular matrix (ECM) obtained from living tissue by removing cellular components and is used as a new biomaterial for biomedical applications. Decellularized tissue products of sheets and powder of various decellularized tissues, such as dermis, urinary bladder matrix, and small intestinal submucosa, have already been used as covering and prosthetic materials clinically. Decellularized tissues show different characteristics from synthetic materials and tissue extracts because the decellularized tissue includes bioactive substances, such as growth factors, extracellular vesicles, and lipid mediators. Recently, decellularized tissue is called decellularized ECM (dECM) and various applications of dECM have been proposed. The dECM hydrogels are prepared from various tissue sources and attempted as injectable hydrogel and 3D-printing bioink. Also, the functionalization of decellularized tissue with synthetic materials, biofunctional molecules, and drugs is attempted while taking advantage of the features of decellularized tissue. In the future, decellularized tissue is expected to be applied to various biomedical fields.
