ABSTRACT
Multicomponent reactions (MCRs) have served as important and powerful synthetic tools for the construction of complex and useful molecules in organic synthesis [1–3]. Compared with the classical approaches (linear, iterative, or divergent synthesis), MCRs carry several advantages. These advantages include producing target compounds in a simple one-pot manipulation, essentially avoiding the isolation of synthetic intermediates and showing high atomeconomy. Several classical reactions, such as the Passerini reaction [4–8], the Ugi reaction [9–11], the Mannich reaction [12, 13], and the Strecker reaction [14, 15], which assemble desired products in a one-pot process from three or more reactants with high efficiency, have been certainly grouped under the term MCRs. In modern synthesis, extensive literature reports have clearly demonstrated the tremendous applicability and value of MCRs [16–26], while at the same time showing the need for developing novel MCRs that are able to broaden the synthetic routes of diverse useful skeletons and structures.
