The aim of this study was to evaluate the use of antiemetic drugs for Postoperative Nausea and Vomiting (PONV) in surgical patients at Dr. Soetomo General Hospital. This cross-sectional, prospective study was conducted from 4 to 25 April 2016 in the recovery room of the Integrated Surgical Center at Dr. Soetomo General Hospital, Surabaya. The inclusion criteria were patients who had undergone surgery and received antiemetic drugs. A total of 179 patients were included in this study, of which 61.0% were female and 39.0% were male. The types of antiemetic drugs used were metoclopramide (41.7%), ondansetron (40.2%), and dexamethasone (18.1%). Six patients experienced PONV, of which four used metoclopramide and two used dexamethasone. No PONV incident occurred when the antiemetic drugs were used alone, but all the six PONV incidents occurred when the antiemetic drugs were used in combination. In conclusion, the therapeutic doses of metoclopramide, ondansetron, and dexamethasone administered for PONV were in accordance with the literature, but not the time of administration. Among seven risk factors, five led to the incidents of PONV.