ABSTRACT

Mycosis fungoides (MF) represent the most common subtype of cutaneous T-cell lymphoma (CTCL), constituting 44% of all diagnoses.1

Routinely, classification of CTCL is obtained on histological and immune-phenotypic grounds of infiltrating lymphocytes and molecular genetics. Differential diagnosis involves a number of different and polymorphic entities, such as chronic eczema, psoriasis, interface dermatitis, and others. Moreover, diagnosis is complicated by an inherent heterogeneity of MF lesions, often expressing subtle histological features that mimic those of other inflammatory or neoplastic skin conditions.