ABSTRACT
The last three decades have seen the development of molecular technologies that have reshaped the diagnostic landscape for neurovirology and neuroinfectious diseases. The advent of high-throughput technologies has led to exciting developments in the field of neurodiagnostics and new methods for pathogen discovery, particularly metagenomic next-generation sequencing and Virscan, a pan-viral antibody testing with phage display. Here, we discuss the technical aspects of these technologies, including their advantages and pitfalls. As these technologies become more widely adopted, it is critical for the clinical neurologist to appreciate the nuances of these technologies in order to allow for appropriate interpretation of their results within the clinical context of their patients.
