ABSTRACT
Microsponges are most commonly prepared by two methods-that is, liquid-liquid suspension polymerization and quasiemulsion solvent diffusion-but some novel techniques were recently developed. Jain and Singh prepared dicyclomine-loaded microsponges for colonic delivery by the quasiemulsion solvent diffusion method to study the effect of process variables and analyzed in vitro drug release data. Various patents were reported on microsponge drug delivery systems, but none of them deals with oral drug delivery. The use of bioerodible and biodegradable polymers for drug delivery is enabling it for the safe delivery of the active material. As these porous systems have also been studied for drug delivery through the pulmonary route, this shows that these systems can show effective drug release even in the scarcity of the dissolution fluid; thus, the colon is an effective site for targeting drug release.
