ABSTRACT
This chapter introduces a new column technology that improves the interface between High Performance Liquid Chromatography (HPLC) and solvent-limited detectors such as the mass spectrometer. Thermospray nebulization is achieved through the vaporization of HPLC eluent as it passes through a narrow-bore tube with heated walls. The expansion of the mobile phase accelerates the velocity of the solvent and atomizes most of the remaining liquid. Concentric flow nebulization was essentially developed by improvements made to the thermospray interface. The chapter discusses the technique of Liquid Chromatography–Fourier Transform Infrared Spectroscopy and Liquid Chromatography–Inductively Coupled Plasma Spectroscopy, which is a new and highly specific hyphenation procedure. It looks at the concept of multiple methods of hyphenation before concluding with a discussion on Liquid Chromatography with Gas Chromatography (LCGC) hyphenation. The interfaces in LCGC systems can be broadly divided into two general groups, with each group containing many subdivisions, within which there are small variations.
