ABSTRACT

Cilia have been an exciting, albeit challenging, field of research for the past twenty years. The number of established and candidate ciliopathy-related genes is now around two hundred and the number of diseases that have been re-classified as Ciliopathies is exceeding thirty. This poses a significant development in cellular biology, since for some years the eukaryotic cilium was considered to be of limited importance. Nowadays, this is no longer believed to be the case and eukaryotic cilia are constantly being connected to more human diseases and are being demonstrated to affect numerous signalling pathways.