ABSTRACT
Cardiometabolic diseases are the principal cause of death globally, and are strongly driven by both genetic and environmental factors, mainly nutritional. Nutrigenetic studies investigate the relationship between genetic variants and diet in modulating cardiometabolic risk. Numerous studies have reported statistically significant gene–diet interactions related to cardiovascular risk factors (obesity, insulin resistance, and dyslipidemias) and more recently some evidence is emerging related to cardiovascular events. However, current advances in this field are hampered by the lack of reproducibility across studies. Here, we describe the current state of the field of nutrigenetics with respect to cardiometabolic disease research using some of the best characterized loci, and outline directions for the translation of this and future findings into new preventive and therapeutic options for cardiometabolic disease.
