ABSTRACT
This chapter discusses an overall scheme of pathological role of advanced glycation end products (AGEs)-Receptor for AGE axis in osteoporosis. Diet has been recognized as a major environmental source of AGEs in humans. Osteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and quality, which could compromise bone strength and subsequently increase the risk of bone fractures. The prevalence and cumulative incidence of osteoporosis are high in postmenopausal women and increases with age. The risk of osteoporosis-related bone fractures is also increased in both type 1 and type 2 diabetic patients. Serum pentosidine level was significantly increased in postmenopausal type 2 diabetic women with vertebral fractures compared with those without fractures, which was independent of BMD, risk factors for osteoporosis, diabetic status, and renal function. Bisphosphonates are potent inhibitors of bone resorption and are one of the most widely used drugs for treatment of osteoporosis.
