ABSTRACT
This chapter outlines the animal models currently employed for the study of C. jejuni in published research, and discuss the advantages and drawbacks of each one, while providing an overview as to what the research community has learned about C. jejuni infection from these research models. One of the difficulties in improving our understanding of campylobacteriosis has been the fact that C. jejuni behaves quite differently depending on its surroundings. Focusing more closely, current research suggests that C. jejuni's preferred location within the intestine is the mucus layer, which segregates the host epithelium from the bacteria and other contents of the lumen. Campylobacter jejuni is a common foodborne pathogen that can trigger serious diarrhea in infected patients. Finally, commercial reagents and assays have been developed specifically for use with mouse models. Many antibodies and diagnostic tools are tailored to mouse biology, allowing for accurate tests and experiments.
