ABSTRACT
The genus Salmonella contains some important foodborne pathogens that have the capability to cause both localized infection and systemic infection in humans and other animals. This chapter focuses on a particular aspect/group of foodborne microbes and toxins namely Salmonella, in relation to their classification, morphology, genomics, biology, epidemiology, clinical features, pathogenesis, diagnosis, and treatment and prevention. As a facultative intracellular pathogen, Salmonella usually enters the host via ingestion of contaminated food. Salmonella infection in humans is associated with gastrointestinal tract infection, enteric fever, bacteremia, local infection, and the chronic reservoir state. A number of in vitro cell models based on established cell lines as well as primary cells have been utilized to unravel the mechanisms of Salmonella entry to the host cells and disease outcome. Laboratory models will continue to play a vital part in helping decipher the host–bacterium interactions, and design improved control strategies against Salmonella infections.
