ABSTRACT
Fasciolosis remains a neglected tropical disease, with an increasing reemergence in many parts of the world. Nevertheless, data concerning the genome and transcriptome from Fasciola hepatica still remain scarce, and several studies have been performed to describe Fasciola hepatica's proteome in more detail using different larval stages of its life cycle. A special interest concerning cross-immunoprotective antigens between Fasciola hepatica and Schistosoma mansoni has been raised during the last few years. The tegument of Fasciola hepatica plays an important role in immune evasion, which is composed by the glycocalyx, which changes its chemical composition during the phases of migration and maturation of the parasite. The diagnosis of human fasciolosis is difficult, as there are no specific symptoms and also because there is no egg-parasite detection in the early phases of infection. Measuring the hepatic damage induced after infection assesses the success of the infection by Fasciola hepatica.
