A Multigram Synthesis of Phenyl 2-azido-3-O-benzyl-4,6-O-benzylidene-2-deoxy-1-thio-α-d-mannopyranoside

N-Acetyl-β-d-mannosaminuronic acid (β-d-ManpNAcA) is an essential rare sugar component of capsular polysaccharides in a number of pathogenic bacteria. ¹ For example, nosocomial infections caused by antibiotic (methicillin)-resistant strains of Staphylococcus aureus (MRSA) are mostly attributed to type 5 and type 8 serotypes, each containing β-d-ManpNAcA in their saccharide structures. ^1e