ABSTRACT
This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book provides a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. It covers solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. The book provides a systematic review of existing theories regarding the interactions between solutes and solvents. It also provides some very useful guidelines for dissolution from the Food and Drug Administration perspective. The book finds formulation techniques used to enhance bioavailability for oral liquid dosage forms and to solubilize water-insoluble drugs for parenteral dosage forms. It explores a systemic review on various controlled-release technologies, which may be suitable to be used on longer-lasting applications of water-insoluble drugs.
