ABSTRACT
This chapter discusses some theoretical and practical considerations in applying the complexation technique, and reviews the certain applications of cyclodextrins-based complexation for insoluble compounds. Based on the type of chemical bonding, complexes can generally be classified into two groups: coordination complexes and molecular complexes. Solubilization by complexation is achieved through specific interactions rather than changes in bulk solvent properties as in other solubilizing systems such as co-solvents, emulsions and pH-adjustment. The presence of the complexing agent may alter the toxicity profile of the drug and vice versa. The cost-of-goods is an important factor to consider in the drug development environment. The use of complexation in overcoming pharmaceutical solubility problems has clear advantages over other means of solubilization. The advances in the area of cyclodextrins research and commercialization will lead to lower costs and bulk production methods, making the technique even more attractive. The commercial viability of complex-containing drug formulations has been established with the marketing of many products.
