ABSTRACT

Astroblastoma is a rare glial tumor of uncertain origin. It is classified as either low or high grade. This classification is based on the cellularity, presence of necrosis, and mitotic figures. Astroblastoma commonly occurs in children and adults. Genetic studies were to some degree helpful in obtaining insights about astroblastoma pathogenesis and histological origin. Astroblastoma presents as any mass-occupying lesion. Diagnosis of astroblastoma can be challenging, because it is rare and shares common features with other glial tumors, especially astrocytoma and ependymoma. The mainstay of treatment of astroblastoma is surgical intervention because most tumors are well circumscribed and not infiltrative. The majority of patients reported in the literature underwent gross total resection. Although the progression for astroblastoma is unpredictable, low-grade tumors tend to be less infiltrative with far fewer symptoms and complications. Almost 27" of patients go through recurrence regardless of their tumor grade. Anaplastic astroblastoma predicts poor prognosis.