ABSTRACT
The diagnosis of gliomatosis cerebri (GC) poses a challenge at times due to the subtle and variable symptoms that represent the diffuse neuronal disruptions. Seizures are the most common presentation. The diffuse nature of GC with no specific symptom pattern makes it difficult to diagnose. Moreover, many cases are misdiagnosed and final confirmation of the diagnosis only comes on autopsy. The diagnosis of GC is a combination of imaging and histological findings. Biopsy can be performed by open or stereotactic method based on the mass effect and the presence of tumor mass in the image. The first surgery a patient may have is a biopsy to extract a sample for diagnosis. Most GC cases can be biopsied easily. GC is a diffuse, aggressive type of glioma with a grim prognosis. Emerging molecular details leading to the development of novel therapeutics such as immunotherapies offer promise for treating GC in the future.
