ABSTRACT
Immunoscintigraphy is of little value in the diagnosis of primary cancers, but may be used for staging in well defined situations because of the possibility of whole body imaging. The main interest of immunoscintigraphy lies in the early detection of recurrence in patients with new symptoms and/or increasing serum tumor markers. Irradiation of normal tissues, especially bone marrow is one of the major limiting factors besides low tumor uptake of monoclonal antibodies in radioimmunotherapy, particularly of solid tumors. Background subtraction by using a second label representing circulating activity was proposed to overcome poor differentiation of tumor uptake from circulating activity. Average sensitivity, specificity and accuracy of immunoscintigraphy reported in ovarian carcinoma are 75%. Several studies have compared the performance of immunoscintigraphy with that of other diagnostic modalities in the detection of recurrent ovarian cancer. The stage of B-cell non-Hodgkin’s lymphoma at diagnosis is one of the important factors to determine treatment as well as prognosis.
