ABSTRACT
This chapter provides an in-depth discussion of animal bioassay methodology, only a brief review of pertinent studies important in occupational toxicology. The concern of the public and Congress over the escalating number of serious accidents due to uncontrolled workplace hazards led to the passage of the Occupational Safety and Health Act (OSHAct) of 1970. Occupational Safety and Health Administration (OSHA) has published proposed regulations that identify 28 workplace carcinogens and proposed permissible exposure limits, established work practices, and medical surveillance requirements for them. The proposed cancer policy stipulated that OSHA would periodically publish a candidate list of potential occupational carcinogens. In 1983, OSHA promulgated the Hazard Communication Standard directing employers in the manufacturing industry to inform their employees of the hazards with which they work. Before the establishment of the American Conference of Governmental Industrial Hygienists in 1938, there was no meaningful governmental surveillance, so the protection of workers was haphazard.
