ABSTRACT
To understand more about the structure and function of the brain is one of the largest challenges for modern science. In the early 1970’s Ralph Adams proposed that electroanalytical techniques could aid in this endeavor by providing a selective way to monitor the concentration of the catecholamines and serotonin, neurotransmitters of considerable importance in the brain. The early work of Adams and his coworkers (1) established techniques such as liquid chromatography with electrochemical detection (LCEC) that are now widely used in a number of different neuroscience laboratories. The topic of this review, in vivo voltammetric measurements of dopamine, also originated in his laboratory.
