ABSTRACT
One area of great promise in microcolumn separations is their use for analysis of discrete biological systems. The direction of research in this area is toward development of capillary electrophoresis with smaller capillary diameters for use as chemical sensors. The low volume capability, sensitive detection schemes, and use of electro-osmotic flow for low-volume injection schemes make this a powerful approach to developing sensors for small biological environments. The principle of the sensor is selectivity by separation (capillary electrophoresis) and sensitivity by detection (electrochemical) (1).
