ABSTRACT
The analysis of controlled drugs using capillary and packed supercritical fluid chromatography interfaced with mass spectrometry was reported by G. A. MacKay and G. D. Reed. They emphasized the advantages of Supercritical Fluid Chromatography (SFC) versus high-performance liquid chromatography such as identification of involatile adulterants and the promise of reproducible SFC-MS. Karlsson et al. reported the supercritical fluid chromatography of methaqualone, cotinine, and reclopride, among other compounds, using capillary columns of different polarities. Detection was either thermionic nitrogen-phosphorus or flame ionization. Steuer et al. used ion-pairing techniques in packed-column supercritical fluid chromatography. They studied the combined effect of ion-pairing reagents and mobile-phase density on the selectivity for a wide range of pharmaceuticals such as pindolol, propranolol, bopindolol, isradipin, and spirapril. Heaton et al. have reported the supercritical fluid chromatography of taxicin I and taxicin II extracted by supercritical fluid extraction of Taxus baccata, the English yew tree.
