ABSTRACT
Mesenchymal stromal/stem cells (MSC) are multipotent cells that may be isolated by different mesodermal tissues, including bone marrow (BM). In experimental models of multiple sclerosis (MS), MSC display tissue-protective and anti-inflammatory features together with the capability of modulating immune responses. Based on these properties, MSC have been proposed for the treatment of MS. A few small studies have been carried out so far demonstrating that MSC transplantation is safe, regardless of the administration route. Data on clinical efficacy are still anecdotal and require larger controlled studies.
