ABSTRACT

Behçet's syndrome is a multifactorial, autoinflammatory, chronic variable vessel vasculitis of unknown etiology characterized by recurrent oral and genital lesions, and internal organs (central nervous system, gastrointestinal tract, pulmonary, and bladder) involvement. While experience is limited, results of hematopoietic stem cell transplantation for Behcet's syndrome has been promising with prolonged remissions in several patients. Hematopoietic stem cell transplantation may be indicated for Behçet's syndrome in the presence of revised international criteria or Behçet`s disease scores greater than 5 or when there is a central nervous system, pulmonary, cardiac, or severe gastrointestinal impairment without response to immunosuppressive treatments and biological agents.