This chapter provides the bioactive compounds in rice waste and their extraction, isolation and utilisation. Crude fiber is one of the major components of rice waste. In straw and husks, it is mostly in the form of crystalline cellulose fiber, which is a good source of processed ethanol. In rice bran, crude fiber is reported to be a good source of dietary fiber (DF). As fiber includes a wide range of complex compounds, many different extraction methods are potentially applicable. DFs can be extracted as whole total fiber, soluble or insoluble fiber using selected extraction solvent. Rice waste contains valuable functional compounds. Protein, dietary fiber and antioxidants are distributed mostly in rice bran and show their potential health benefits in reference to diabetes, obesity, gastronomy and cancer. The potentially useful bioactive compounds can be extracted from rice waste based on physical, chemical and biological principles. Although various extraction methods have been developed, their efficiency and yield need to be improved.