The isolation and characterization of bioactive compounds will be a necessary step to increase the value and justify the commercial application in pharmaceutical, cosmetic and food industries. In recent years, with the development of miniaturization/simplification, different extraction techniques, such as ultrasound-assisted, microwave-assisted, supercritical fluid and accelerated solvent extraction, have been developed for the recovery of bioactive compounds from wineindustry waste. The solvent extraction technique, also known as solid-liquid extraction (SLE), comprises a mass transport phenomenon in which migration of compounds through a solid matrix towards a liquid solvent system occurs. Extracts from extraction processes have many bioactive compounds, so isolation and/ or concentration of specific chemical groups sometimes is required because individual polyphenols exhibit different functionalities and chemical activities Fontana et al. The recovery of bioactive compounds from winemaking waste represents a frontfacing challenge for scientists and industries. The implementation of sustainable alternatives to recover compounds and add values to these residues is a complex approach depending on several parameters.