ABSTRACT
This chapter focuses on elaboration of the tumor-specific barriers, the factors implicated in enhancing the transbarrier trafficking of nanosystems with specific regard to cancer chemotherapy, as well as progressive methods for quantifying the resultant nanoparticles (NP) uptake by cancer cells. The physicochemical barrier additionally affects the formation of a geometrical barrier wherein the tumor space is divided into viscous and non-viscous regions causing heterogeneity in the nanomedicine distribution. The chapter also focuses on specific nanostrategies for enhancing transbarrier trafficking for enhanced cancer therapy. It highlights that having a knowledge of the physical parameters of a patient's tumor would be essential in providing personalized oncological care, as a specific NP architecture could be fabricated for the apt tumor conditions. The chapter also highlights the interplay between the physicochemical properties of the NPs as well as the tumor/cell type.
