ABSTRACT

The development of biomaterials has seen many rapid advances and changes in approach over the past decade. Through the use of 3D printing and 3D bioprinting, the size of scaffolds that can be readily fabricated is steadily increasing. Recent work has focused on fabricating engineered tissues that are no longer single materials but are multi-material composites to address this increased need for nutrient exchange in vitro and in vivo. There are many techniques to address this need for increased complexity while developing materials that take cues from nature. One method that will see a much more widespread adoption may be the use of decellularized tissues. Advances in fabrication techniques utilizing the next generation of biomaterials will provide much needed insight into interfacial biology, complex tissue engineering, and vascularization of large tissues to address critical questions for the transition from the bench to bedside in regenerative medicine.