ABSTRACT
This chapter presents a brief overview of the current knowledge as to the mechanisms regulating store-operated Ca2+ entry (SOCE) during cell cycle from cellular proliferation to metastasis with an emphasis on SOCE regulation during cell division. The level of Ca2+-signaling remodeling in cancer cells is remarkable and is associated with dysregulation of several Ca2+channels and pumps. The relationship between SOCE and cell proliferation is an intimate one that goes beyond the well-recognized roles of Ca2+ signaling in cellular growth and proliferation. SOCE is dramatically downregulated during the division phase of the cell cycle through mechanisms that have not been fully elucidated. Aside from the role of maturation promoting factor in SOCE inhibition, very little was known regarding the mechanistic regulation of SOCE inactivation during M-phase. SOCE affects hallmarks of cancer progression, including cell cycle progression, escaping apoptosis, tumorigenesis, metastasis, angiogenesis, and tumor immunity.
