Given the multifactorial nature and the complexity of the aging processes, it would be simplistic to assume that the consumption of high levels of single nutrients or specific food items would be able to modulate the many pathways involved therein. Instead a diverse and naturally occurring dietary pattern, such as the Mediterranean diet, provides practitioners with a model that's well documented for its range of beneficial actions on gut, brain, and systemic health. This chapter describes the context of age-related disorders with a specific focus on brain aging. It describes integrative practitioners with an insight as to how this model is a much better fit for ongoing neuroprotection mediated by means of ongoing minimization of genomic instability, sustained protection of genomic integrity and wholefoods. The chapter deals with the use of targeted nutraceuticals, prescribed on the basis of individual requirements.