ABSTRACT
This chapter reviews the application of the microfluidics device and chips for detecting infectious diseases. A droplet-based device has dimensional scaling benefits which enable rapid and controlled mixing of fluids in the droplet reactors. Chemiluminescence-based microfluidic devices are based on using light emitted from the chemical reaction. Colorimetric-based microfluidic systems have also been utilized for the detection of malaria. Absorbance approaches like colorimetric detection are based on the color change of the detection system. Lens-less shadow imaging is another approach of using a microfluidic device by leveraging the potential of charge-couple device sensor and microfluidic device for point-of-care applications. Electrical sensing in microfluidic chips is insensitive to light intensity, cheaper, simpler, and a powerful modality to create sensitive portable biosensors. Microfluidic systems offer numerous advantages in medical diagnosis and bioanalytical applications, including minimal manual user intervention, lower sample consumption, shorter assay time, and enhanced data analysis and processing with full automation and portability.
