ABSTRACT
Porphyrias and lupus erythematosus (LE) are the only dermatologic conditions in which HRT should not be used (1,2,6,7). Although a few studies suggested that estrogen replacement does not increase the risk for lupus ares in postmenopausal women with LE (8-10), HRT and ERT may be responsible for clinical and biologic accentuations in women with lupus, and for a ‘rst manifestation of the disease in women with no past history. Melasma was evidenced in women under HRT (11).
