ABSTRACT
During ovarian stimulation for in vitro fertilization (IVF), the development of multiple follicles leads to abnormal hormonal levels. If these levels adversely affect the probability of implantation, then this may lead to implantation failure either by altering endometrial receptivity and/or oocyte/embryo quality.
It appears that no association seems to exist between low endogenous luteinizing hormone (LH) levels and pregnancy achievement in gonadotropin-releasing hormone (GnRH) analogue cycles. Thus, its involvement in recurrent implantation failure (RIF) appears unlikely, while its assessment does not offer useful information other than the confirmation of downregulation.
Moreover, although an adverse effect of high estradiol (E2) concentration on endometrial receptivity as well as on oocyte/embryo quality has been reported, it appears that the majority of published studies do not support an association between E2 levels on the day of triggering and the probability of pregnancy.
However, it should be emphasized that studies addressing the association of LH and E2 levels during ovarian stimulation for IVF specifically in patients with RIF have not been performed.
