ABSTRACT
Matrix metalloproteinases (MMPs), also called matrixins, are zinc-containing endopeptidases which function in the extracellular space in a number of tissues to degrade a variety of extracellular matrix (ECM) protein components. They play a central role in development, wound healing, tissue repair, and in a number of disease processes, such as arthritis, cancer, myocardial infarction, and skin aging. MMPs are classified based on structure and substrate specificity into the collagenases (MMP-1, -8, and -13); gelatinases (MMP-2 and -9); stromelysins (MMP-3, -10, and -11); matrilysins (MMP-7 and -26); and membrane-type (MT) (MMP-14, -15, and -16). MMPs are implicated in the degradation and alterations of ECM that contribute to rhytids, laxity, and photoaging. MMP inhibition is a target for the treatment of cutaneous aging.
