ABSTRACT
This chapter focuses on the current use of regenerative therapies in horses and dogs, which are the species with diseases, lifestyles and access to advanced orthopedic healthcare most similar to us. Similar to in human medicine, osteoarthritis and tendinopathy are the two orthopedic diseases most commonly treated with regenerative therapies in veterinary patients. The chapter synthesizes the experimental and clinical research findings, and how these advances can be applied to human pathophysiology. The synthesis of human medicine with veterinary medicine, and its corresponding benefit to all species, is a hallmark of the "One Health" concept. Dogs and horses are the most commonly treated veterinary species for orthopedic disease and injury. Regenerative medicine aims to harness the body's own anti-inflammatory and regenerative machinery to (1) reduce inflammation and scarring to treat conditions due to chronic inflammation and (2) promote healing in sites that have poor regenerative capacity.
