ABSTRACT

Omics technologies are high-throughput technologies that have enabled large-scale and genome-wide association studies of regulation on multiple levels in both cells and tissues. Placenta, as a fundamental organ in sustaining fetal development and a mediator of fetal programming, has frequently been investigated using diverse omics approaches, especially to uncover the influence of maternal diabetes. Here we summarize and discuss the results of those studies, with a focus on recent developments in placental exosomics and microRNA research. We aim to give an overview of advantages and limitations of omics technologies and information on the potential confounders in data analysis.