ABSTRACT
Metal nanoparticles such as aluminium, copper, gold, magnesium, silver, titanium and zinc are known for their antimicrobial activity. Recently, scientists are working hard towards the development of nano-antibiotics and other nano-formulations. Bacterial infections cause millions of severe illness worldwide which leads to the mortality of people including children every year. Development in nanotechnology made production of nanoparticles more cost-effective, and therefore, they have been applied as antimicrobial agents. Functionalized nanoparticles or conjugated nanoparticles can act as excellent candidates for drug delivery or targeted therapy. Nanoparticulate drug delivery approaches grasp significant potential for the treatment of bacterial infections. Nanoparticles based drug delivery systems carried out controlled drug release in organs or tissues and deliver bioactive agents. The nanoparticles when conjugated or functionalized with antibiotics exert enhanced and remarkable antibacterial activity. In addition, the functionalized nanoparticles are excellent candidates for drug delivery. The functionalization of nanoparticles by different drugs/antibiotics is an emerging field for combating multidrug resistance problem in bacteria.
