ABSTRACT
A critical onset process of Alzheimer’s disease is the formation of insoluble fibrillar deposits of the amyloid beta peptide (Aß) as both diffuse and senile amyloid plaque that invades the brain’s seat of memory and cognition. As demonstrated in the transmission electron microscopy images, Aß-coated gold colloids that exist dispersely under pH 10 exhibited reddish color. With pH 4, however, the gold colloids showed a bluish color due to the formation of aggregates caused by the networking of Aß adsorbed on the surface. Conformation constricted over the nanocolloidal surface possesses the size dependence. Since the formation of the intermediates can be regarded as the transition state with relatively higher thermal energy, the reversible process is expected to take place at relatively higher temperatures. If temperature is shifted from 5°C to 45°C, the monomers located over the surface of the colloidal surface should attempt to form the most stable form in order to create a new equilibrium.
