ABSTRACT

Directional statistics has been applied in several different branches of biology [2], including the modelling of periodic properties in biological tissues [19], movement of organisms [47], and in the study of circadian rhythms, such as wake-sleep cycles [32]. In this chapter we will outline several usages of directional statistics in protein bioinformatics, which is a field dealing with the

Methods and

modelling and prediction of the three-dimensional structure of proteins. We will first give the biochemical background for studying these biological macromolecules and then we will outline different approaches to molecular modelling making use of methods from directional statistics. We will conclude the chapter with a discussion on related research and open challenges.